Therapeutic advances in Dravet syndrome: a targeted literature review

Mortality in Dravet syndrome: A review

INTRODUCTION Premature mortality is a major issue in Dravet syndrome (DS). To improve understanding of DS premature mortality, we conducted a comprehensive literature search with a particular emphasis on SUDEP. METHODS We searched PubMed, Embase, Web of Science, Cochrane, CENTRAL, CINAHL, PsycINFO, Academic Search Premier, and ScienceDirect on the following terms: "Dravet syndrome", "severe m...

Current therapeutic procedures in Dravet syndrome.

Dravet syndrome is a highly pharmaco-resistant form of epilepsy. Valproate and benzodiazepines are the first-line treatment but are usually insufficient therapeutic options. Lamotrigine, carbamazepine and high doses of intravenous phenobarbital can aggravate seizures and should be avoided. Topiramate, levetiracetam, bromide and ketogenic diet also provide substantial efficacy as adjunctive ther...

Advances in Targeted Drug Delivery

Advances in Targeted Drug Delivery

Advances in the Aetiophatogenesis of Sjögren's Syndrome: a Literature Review

OBJECTIVES The purpose of present paper is to review and critically address the recent advances on the aetiopathogenesis of the Sjögren's syndrome, taking into account the attained clinical features, with particular relevance given to the oral involvement. MATERIAL AND METHODS A comprehensive review of the available literature between 1970 and 2012, regarding to the aetiopathogenesis and clin...